Karakterisasi dan Formulasi Nanopartikel Ekstrak Tanaman Bundung (Actinoscirpus grossus) dengan Variasi Konsentrasi Basis Kitosan dan Na-TPP Menggunakan Metode Gelasi Ionik

Bundung plant extract contains flavonoid secondary metabolite compounds that have the potential to kill Staphylococcus aureus bacteria and inhibit fungus Candida albicans. Its utilization uses nanoparticle technology because ability penetrate cell walls can be penetrated by size of colloidal particles. Nanoparticles are technologies a 10-1000 nm. The formation nanoparticles using chitosan polymer Na-TPP produce preparations with good stability. This study aims determine characterization formulation effect concentration on extracts. research is an experimental laboratory quasi-experimental design method one-group posttest-only design. extracts formulated into various concentrations formula 1 (chitosan 0.1% 0.2%), 2 0.15% 0.15%), 3 0.2% 0.1%). Then organoleptic tests were carried out in particle tests, zeta potential, data analyzed ANOVA. All formulas showed size. results F2 was smallest 328.8 nm, but for value, stable F3 it had value close +/-30mV, i.e., 10.4mV. statistical One Way ANOVA show significance <0.05, which means there variations Na-TPP. Variations each affect value.